Canine Epidermolysis Bullosa Acquisita

  
An intact vesicle biopsy specimen taken from an urgently referred, young Great Dane with an acute onset, severe, ulcerative skin disease

This is a routinely stained section through the single intact blister on the pinna, indicating the subepidermal blistering disease, providing a provisional histopathology diagnosis within 72 hours of disease onset

A spectacular photomicro-graph, taken at North Carolina State University, displaying IgG autoanti-bodies targeting a specific layer of the skin in this very rare blistering disease, This special immunohisto-chemistry test was required for definitive proof of one of the first cases of this disease seen in the UK